Advantages of Protein Solution Crystallization

Crystallization is a common chemical process, manymacromolecules, their unique features more and more
industrial products such as inorganic fertilizer, sodaattention. As we all know, depends primarily on
ash, chemical reagents, rubber, rubber, polymers andmolecular features of its unique three-dimensional
plastics, vitamins, construction materials, explosivesstructure. Therefore, to understand the function of
manufacturing, and the crystallization process is adetermining that a biological macromolecules, we
very close relationship. As typical chemical processmust examine and determine its three-dimensional
unit operations, crystal has the following advantages:structure.
? energy consumption. Most compounds is anOn the other hand, understanding the structure of
exothermic crystallization process, and distillation,biological macromolecules for drug design, molecular
drying, energy consumption compared to large unitstructure and to change or modification of a specific
operations, distillation crystalline phase transitionapplication features are of great importance. X-ray
potential is only 1/3 to 1/7, only energy intensivediffraction to determine molecular three-dimensional
separation RUN 10 ~ 30%.crystal structure of the most reliable method, but so
? apply to azeotrope separation of complex systemsfar for X-ray diffraction of protein crystals of
and so on. Since nearly 90% of the organicbiological macromolecules in this area was still one of
compounds for the eutectic-type system, usingthe main technical bottlenecks, severely restricting
ordinary distillation methods can not achieve theirthe protein engineering, rational drug Design, synthesis
goals. Use of extraction, azeotropic distillationand design of new vaccine development of
although other methods can be separated in theory,biotechnology. Protein crystallization is a complex
but the operation by the extraction solvent selection,physical and chemical processes, than the
the actual conditions in the difficult objective tocrystallization of small molecule compounds, much
achieve complete separation; Moreover, themore difficult, mainly because of its molecular weight
extraction agents of other components of theand molecular conformation of complex, static
introduction of extended process line, to increasecharacteristics, physical and chemical properties of the
investment and operating costs, and inevitably affectinstability itself with cofactor, ligand, and other special
the quality of the final product. And distillation,factors, many of the protein crystallization process is
extraction compared to the crystallization processeasy to lose in the activity of protein crystal growth
does not introduce other substances, the highso that the work difficult.
selectivity of the crystallization operation, can beOften get the following results: amorphous
prepared from high purity or ultra-pure products (=precipitation, a large number of ceramics, twinning,
99. 9% pure products chromatography).multiple crystal fusion of body, or defective single
? Crystal operating temperature lower, the smallcrystals. Therefore, in general terms, the current
degree of corrosion of equipment.biological macromolecules such as protein crystal
? improve the operating environment, reducegrowth is still groping and empirical, to some extent
environmental pollution. Solution crystallization processalso on the opportunity.
by changing the operating conditions or the additionCrystal growth has become the obstacle to the
of seed material to make the system criticaladvancement speed of the crystal structure analysis
components of solubility (or super saturation)of the key issues.
changes, the system changes from the steady-stateCoach outlet stores are always the best place for
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