An Overview of Good Drug Manufacturing Practice

Scientists and professionals in the biotechnology,laboratory professionals have a fundamental
biopharmaceutical and pharmaceutical industries applyunderstanding of the basis of the regulations, as well
strict guidelines for good practices in drugas the conditions that necessitate them.
manufacturing.Drug manufacturing firms must have a quality control
Also known as cGMP, the high standards require, atunit for each drug development project that
the very least, compliance with the strict regulationsguarantees consistency and adherence to
of state agencies such as the US Food and Drugspecifications, set by the client firm and US law.
Administration (FDA). The Federal government hasDuring manufacture, records must be made manually
also issued as minimum requirement compliance withor through instrumentation. Good documentation is an
quality and safety standards in drug manufacture.essential element of cGMP, as this assures the
This includes standards in methods, facilities, andtraceability of the complete history of a product
controls that are applied from the formulation to thebatch, as well as the defined procedures in each
packaging of the drug. Effective compliancephase of the production.
techniques are essential in the development of safe,One of the basic marks of a reputable pharmaceutical
high quality pharmaceutical products.manufacturing firm is the practice of good
There are various aspects of cGMP regulations,manufacturing standards. The firm must have staff
including the manufacturing operations, personnel andand facilities that meet the highest levels of
facilities, and laboratory validation. In assuringregulatory compliance, as well as the clients' quality
compliance with standards in Good Manufacturingassurance audits for drug manufacturing.
Practice, it is essential that all managerial and